Editors:
- Spotlights a rapidly growing field with increasing importance in basic and translational biology
- Contains key protocols and clear cut guidance
- Supports the development of therapeutics for dominant genetic disorders, cancer, or viral infection
- Includes supplementary material: sn.pub/extras
Part of the book series: Neuromethods (NM, volume 58)
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Table of contents (10 protocols)
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Front Matter
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Back Matter
About this book
Non-coding, inhibitory microRNAs have emerged as important modulators of cellular gene expression, through a process called RNA interference (RNAi).  To date, hundreds of conserved and species-specific microRNAs have been identified in organisms ranging from single-celled algae to humans.  Many of these tiny RNAs are now known to play fundamental roles in developmental biology and disease pathogenesis.  In addition, RNAi has emerged as a technology useful for manipulating gene expression.  In RNA Interference Techniques, expert researchers present detailed methods for designing and delivering artificial inhibitory RNAs to neural tissue and for detecting or cloning endogenous microRNAs, all in order to aid investigators’ attempts to ask basic biological questions or develop therapeutics for dominant neurogenetic disorders, cancer, or viral infection. As a volume in the successful Neuromethods series, the chapters provide authoritative accounts of the most commonly used approaches in the field today.
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Cutting-edge and concise, RNA Interference Techniques promises to support the vital research in the field of RNAi and miRNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.
Editors and Affiliations
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Research Institute, Center for Gene Therapy, Nationwide Children’s Hospital, Columbus, USA
Scott Q. Harper
Bibliographic Information
Book Title: RNA Interference Techniques
Editors: Scott Q. Harper
Series Title: Neuromethods
DOI: https://doi.org/10.1007/978-1-61779-114-7
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC 2011
Hardcover ISBN: 978-1-61779-113-0
Softcover ISBN: 978-1-4939-5762-0
eBook ISBN: 978-1-61779-114-7
Series ISSN: 0893-2336
Series E-ISSN: 1940-6045
Edition Number: 1
Number of Pages: XII, 173
Topics: Neurosciences, Human Genetics