Overview
- An easily accessible reference volume for the latest diagnostic and research techniques for studying hematological malignances as written by leading researchers in the field
- Systematic and reliable molecular approaches for molecular diagnosis and monitoring of minimal residual disease (MRD)
- Comprehensive global analyses of cancer genome, epigenome and expression profiling of leukemic cells
- Inclusive guides to disease modeling using normal murine and human primary hemateopoietic cells as well as patient samples
- State-of-art approaches for identification and characterization of both normal hematopoietic and leukemic stem cells
- Detailed protocols to characterize critical interacting partners, downstream targets and epigenetic functions of leukemia associated transcription factors
Part of the book series: Methods in Molecular Biology (MIMB, volume 538)
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Table of contents (21 protocols)
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Front Matter
Keywords
About this book
Recent advances in molecular and cellular biology techniques have significantly improved our ability to detect, monitor, model and study the underlying molecular basis and pathogenesis of leukemia, yet we are still in an early discovery stage and much more work is needed in order to develop better strategies to diagnose, classify and treat this biologically and clinically diverse disease. In Leukemia: Methods and Protocols, expert researchers bring together a wide range of state-of-the-art laboratory methods and detailed protocols that are useful for both clinical and basic research scientists working on the disease. The volume provides techniques for prenatal backtracking of leukemic clone, molecular diagnosis, detection of genome-wide genetic abnormalities and profiling, identification of unknown fusion genes, monitoring of minimal residual diseases, disease modeling using murine and human primary hematopoietic cells, studying of normal and malignant hematopoiesis, identification of interacting partners with leukemia associated oncoproteins, and global characterization of genome-wide epigenetic changes in leukemic cells. Written in the highly successful Methods in Molecular Biology™ series format, the convenient chapters contain brief introductions, lists of the necessary materials, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.
Comprehensive and cutting-edge, Leukemia: Methods and Protocols will help researchers to advance knowledge and have a better understanding of the disease, which will ultimately facilitate development of anti-cancer therapy and improve quality of life for patients.
Bibliographic Information
Book Title: Leukemia
Book Subtitle: Methods and Protocols
Editors: Chi Wai Eric So
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-59745-418-6
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Humana Press 2009
Hardcover ISBN: 978-1-58829-989-5Published: 01 April 2009
Softcover ISBN: 978-1-4939-5630-2Published: 23 August 2016
eBook ISBN: 978-1-59745-418-6Published: 11 March 2009
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XI, 434
Topics: Cancer Research, Oncology, Laboratory Medicine