Overview
- Focuses on key assays in genotoxicity and DNA repair
- Places special emphasis on the analysis of nanoparticles and nanomaterials
- Features reproducible techniques and expert implementation advice
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Pharmacology and Toxicology (MIPT)
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Table of contents (25 protocols)
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Front Matter
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Genotoxicity Assays
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Front Matter
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Keywords
About this book
Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the “OECD guidelines for the testing of chemicals”, this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab.
Authoritative and invaluable, Genotoxicity and DNA Repair: A Practical Approach aims to aid scientists in their pursuit of forwarding this vital field of study.
Editors and Affiliations
Bibliographic Information
Book Title: Genotoxicity and DNA Repair
Book Subtitle: A Practical Approach
Editors: L. María Sierra, Isabel Gaivão
Series Title: Methods in Pharmacology and Toxicology
DOI: https://doi.org/10.1007/978-1-4939-1068-7
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-1-4939-1067-0Published: 22 August 2014
Softcover ISBN: 978-1-4939-4829-1Published: 17 September 2016
eBook ISBN: 978-1-4939-1068-7Published: 21 August 2014
Series ISSN: 1557-2153
Series E-ISSN: 1940-6053
Edition Number: 1
Number of Pages: XII, 483
Number of Illustrations: 28 b/w illustrations, 42 illustrations in colour
Topics: Pharmacology/Toxicology, Human Genetics