Editors:
- Includes cutting-edge methods and protocols
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 1140)
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Table of contents (25 protocols)
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Front Matter
About this book
Structural Genomics and Drug Discovery: Methods and Protocols focuses on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Structural Genomics and Drug Discovery: Methods and Protocols seeks to aid scientists in the further study into structural genomics approach as an efficient initial step toward drug discovery and the methods described will be useful to anyone interested in moving in this direction.
Keywords
- Structural Genomics
- bio-informatics
- cloning
- crystallization screening
- data management
- drug discovery
- expression and solubility testing
- genome sequencing
- macromolecular structure determination
- protein production
- purification
- screening for suitability for NMR structure determination
- structure aided drug discovery
- structure determination methods
Editors and Affiliations
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Center for Structural Genomics of Infectious Diseases Midwest Center for Structural Genomics, Northwestern University Feinberg School of Medicine, Chicago, USA
Wayne F. Anderson
Bibliographic Information
Book Title: Structural Genomics and Drug Discovery
Book Subtitle: Methods and Protocols
Editors: Wayne F. Anderson
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-4939-0354-2
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, New York 2014
Hardcover ISBN: 978-1-4939-0353-5Published: 04 March 2014
Softcover ISBN: 978-1-4939-4462-0Published: 30 April 2017
eBook ISBN: 978-1-4939-0354-2Published: 08 July 2014
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XV, 344
Number of Illustrations: 14 b/w illustrations, 64 illustrations in colour
Topics: Pharmacology/Toxicology, Human Genetics