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Microwave-Assisted Synthesis: General Concepts

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Microwave-assisted Polymer Synthesis

Part of the book series: Advances in Polymer Science ((POLYMER,volume 274))

Abstract

Microwave heating is proving to be a valuable technique in preparative chemistry. Using a modern scientific microwave apparatus it is possible to access elevated temperatures in an easy, safe and reproducible way. By using microwave heating, reaction times can often be decreased, product yields increased and purity enhanced as compared with conventional heating methods. The origins of the rate enhancements observed have been a topic of considerable debate over the years. It is now accepted, however, that microwave heating is just that – heating. As well as giving an overview of the physical chemistry concepts behind microwave heating, this chapter explores the key tenets of microwave-assisted organic chemistry in the context of particular classes of reaction. The chapter discusses topics such as metal catalysis, cycloaddition and condensation reactions, use of gases as reagents, combinatorial chemistry and reaction scale-up.

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Abbreviations

GHz:

Gigahertz

MW:

Microwave

ppb:

Parts per billion

ppm:

Parts per million

UV:

Ultraviolet

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  1. Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT, 06269-3060, USA

    Nicholas E. Leadbeater

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  1. Department of Organic Chemistry Supramolecular Chemistry group, Ghent University, Ghent, Belgium

    Richard Hoogenboom

  2. Institute for Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, Jena, Germany

    Ulrich S. Schubert

  3. Polymer Competence Center Leoben GmbH, Leoben, Austria

    Frank Wiesbrock

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Leadbeater, N.E. (2014). Microwave-Assisted Synthesis: General Concepts. In: Hoogenboom, R., Schubert, U., Wiesbrock, F. (eds) Microwave-assisted Polymer Synthesis. Advances in Polymer Science, vol 274. Springer, Cham. https://doi.org/10.1007/12_2013_274

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