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Glutamate Receptors in Peripheral Tissue: Excitatory Transmission Outside the CNS pp 233–241Cite as

Platelet Glutamate Receptors as a Window into Psychiatric Disorders

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3. Conclusion

Much research remains to be done. The state trait nature of the marker needs to be elucidated. It would be illuminating to know if the marker settled with improvement in clinical condition. Treatment specificity with regard to the marker would also be interesting. It would be illuminating to know if the marker had any predictive value in terms of treatment. More research in a wider range of psychiatric illnesses would be interesting. It is also necessary to look at studies to correlate the peripheral marker with central markers to validate the use of peripheral markers.

It is hoped that platelet intracellular second messenger responses to glutamate will reflect the pathogenesis of the disease processes. Further development of these accessible and practical markers may allow for a better understanding of these disorders, and may guide in the rational development of treatments of these conditions.

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Authors and Affiliations

  1. Barwon Health and Geelong Clinic, Department of Clinical and Biomedical Sciences, University of Melbourne and Community and Mental Health, Barwon Health Swanston Centre, PO Box 281, Geelong, Victoria, 3220, Australia

    Michael Berk (Professor of Psychiatry)

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  1. Michael Berk
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Editors and Affiliations

  1. Toxicology Research Division, HPFB, Health Canada, Ottawa, Canada

    Santokh Gill  & Olga Pulido  & 

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Berk, M. (2005). Platelet Glutamate Receptors as a Window into Psychiatric Disorders. In: Gill, S., Pulido, O. (eds) Glutamate Receptors in Peripheral Tissue: Excitatory Transmission Outside the CNS. Springer, Boston, MA. https://doi.org/10.1007/0-306-48644-X_15

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