Research ArticlesA drug release study from hydroxypropylmethylcellulose (HPMC) matrices using QSPR modeling
Section snippets
INTRODUCTION
A method of obtaining a sustained‐release product is to embed or disperse the solid medicinal compound in an insoluble matrix by compression of a physical mixture of the compound and a polymeric material.1 This has attracted considerable attention and has been described by several researchers.2., 3., 4., 5. Matrix tablets have long been used to obtain sustained drug delivery and it was Higuchi who first presented a detailed mathematical analysis of this release.6
Hyroxypropylmethylcellulose
Materials
Acetaminophen (Acros Organic, UK), diclofenac sodium (Sobhan Co., Iran), fluoxetine HCl (Pars‐Daru, Iran), naproxen (Pars‐Daru, Iran), piroxicam (Sigma, USA), propranolol HCl (Acros Organic, UK), sulfamethoxazole (Logman, Iran), diltiazem HCl (Acros Organic, UK), ibuprofen (Acros Organic, UK), atenolol (Daru‐Pakhsh, Iran), diphenhydramine HCl (Acros Organic, UK), imipramine HCl (Logman, Iran), theophylline monohydrate (Acros Organic, UK), trifluoperazine HCl (Sobhan Co., Iran) and trimethoprim
RESULTS AND DISCUSSION
Various factors could be accounted for the drug release mechanism from hydrophilic matrices.16 These include the geometry of the matrix,17 particle size of polymer and matrix swelling ratio (which depends on the HPMC type and controls water and drug diffusion coefficients),18, 19 polymer and drug concentrations,20, 21 chain length and degree of substitution of the HPMC,19 as well as the drug characteristics.22, 23 An additional factor that might affect the drug release profile is the
CONCLUSION
The process of drug release from HPMC matrices involves the two routes of erosion of the matrix, and diffusion of the dissolved drug through the HPMC gel, each to a varying extent depending on the properties of the drug as well as the polymer grade. QSPR method employed in this investigation was able to outline the major drug properties responsible for the control of release from HPMC matrices. These included drug solubility and the molecular size, with enhancing and reducing effects on the
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